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Senior Director, Medicinal ChemistryApplylocations: Oxford, United Kingdomtime type: Full timeposted on: Posted Todaytime left to apply: End Date: August 14, 2026 (24 days left to apply)job requisition id: REQ-29648Job DescriptionGENERAL SUMMARY:We are seeking a highly motivated and experienced Medicinal Chemistry leader to join our group at Vertex Oxford at the Senior Director level. Reporting to the Head of Medicinal Chemistry, you will lead a highly skilled and motivated medicinal chemistry team to discover high quality clinical candidates that progress into clinical trials. You will have a track record of success across multiple projects from Hit ID to Candidate delivery. You will lead, develop, and implement state of the art medicinal chemistry strategies, providing key expertise in medicinal chemistry and related disciplines (DMPK, biology, computational chemistry, process chemistry). You will help drive the development of our internal talent through continuous teaching and mentorship.You may also take on wider project leadership responsibility, driving a multi-disciplinary project team, accountable to the Site Head for the overall strategy and delivery of a key project within our portfolio.KEY RESPONSIBILITIES: Drive state of the art chemistry design and synthesis to rapidly deliver high-quality clinical candidates. Exercise exceptional judgement based on significant medicinal chemistry experience to ensure your team delivers molecules with low predicted human doses and overall profiles that enable rapid progression through pre-clinical safety assessments and into clinical trials Drive and motivate your team of medicinal chemists to deliver molecules using efficient synthetic routes, ensuring smooth transition to scale up teams to enable rapid progress and delivery to project goal timelines. Provide dynamic leadership of a multidisciplinary drug-discovery team working on a key project within our portfolio.SKILLS & EXPEREINCE: Qualifications in Organic or Medicinal Chemistry with extensive experience working in a pharmaceutical and/or biotechnology setting as a medicinal chemist. Leadership of medicinal chemistry teams with a strong record of scientific accomplishment and success delivering clinical candidates. Experience from Hit ID to candidate delivery, with deep knowledge of both molecular properties and drug substance solid form. Expert knowledge of medicinal chemistry literature, organic synthesis, and methodology, with good working knowledge of DMPK, biology, computational chemistry, and structure-based drug design. A concise and effective communication style to provide teams with clear guidelines, energy, drive, and motivation. Strong interpersonal teamwork and organizational skills, with ability to thrive in a dynamic, fast-paced, innovative environment. Ability to manage timelines and drive projects to rapidly answer key questions.Flex Designation:On-Site DesignatedFlex Eligibility Status:In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.#LI-OnsiteCompany InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com### About Vertex## Help Us Achieve Our Mission## Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency *.Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook,* Twitter/X *, LinkedIn, YouTube and Instagram.The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives.*Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work. #J-18808-Ljbffr

\n GENERAL SUMMARY\n We are seeking a highly motivated and experienced Medicinal Chemistry leader to join our group at Vertex Oxford at the Senior Director level. Reporting to the Head of Medicinal Chemistry, you will lead a highly skilled and motivated medicinal chemistry team to discover high quality clinical candidates that progress into clinical trials. \n You will have a track record of success across multiple projects from Hit ID to Candidate delivery. You will lead, develop, and implement state‑of‑the‑art medicinal chemistry strategies, providing key expertise in medicinal chemistry and related disciplines (DMPK, biology, computational chemistry, process chemistry). \n You will help drive the development of our internal talent through continuous teaching and mentorship. You may also take on wider project leadership responsibility, driving a multi‑disciplinary project team, accountable to the Site Head for the overall strategy and delivery of a key project within our portfolio. KEY RESPONSIBILITIES\n \n • Drive state‑of‑the‑art chemistry design and synthesis to rapidly deliver high‑quality clinical candidates.\n, • Exercise exceptional judgement based on significant medicinal chemistry experience to ensure your team delivers molecules with low predicted human doses and overall profiles that enable rapid progression through pre‑clinical safety assessments and into clinical trials.\n, • Drive and motivate your team of medicinal chemists to deliver molecules using efficient synthetic routes, ensuring smooth transition to scale‑up teams to enable rapid progress and delivery to project goal timelines.\n, • Provide dynamic leadership of a multidisciplinary drug‑discovery team working on a key project within our portfolio.\n SKILLS & EXPERIENCE\n \n, • Qualifications in Organic or Medicinal Chemistry with extensive experience working in a pharmaceutical and/or biotechnology setting as a medicinal chemist.\n, • Leadership of medicinal chemistry teams with a strong record of scientific accomplishment and success delivering clinical candidates.\n, • Experience from Hit ID to candidate delivery, with deep knowledge of both molecular properties and drug substance solid form.\n, • Expert knowledge of medicinal chemistry literature, organic synthesis, and methodology, with good working knowledge of DMPK, biology, computational chemistry, and structure‑based drug design.\n, • A concise and effective communication style to provide teams with clear guidelines, energy, drive, and motivation.\n, • Strong interpersonal teamwork and organizational skills, with ability to thrive in a dynamic, fast‑paced, innovative environment.\n, • Ability to manage timelines and drive projects to rapidly answer key questions.\n Flex Designation / Eligibility Status\n On‑Site Designated Flex Eligibility Status: In this On‑Site designated role, you will work five days per week on‑site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. Equal Employment Opportunity Statement\n Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. \n #J-18808-Ljbffr

Chemist Pilot Plant 24-25k South East ABJ6515A TEMP- 6 months on site An excellent opportunity for an early-career chemist to join a dynamic and supportive team within a modern laboratory environment. This role is ideal for a chemist with a background in chemistry, biochemistry or manufacturing who is looking to develop hands-on experience in formulation, blending, and analytical testing. As chemist - lab technician you will play a key role in supporting laboratory operations while gaining exposure to wider technical and technology teams in a global setting. As a chemist - Laboratory Technician / Lap Operator in an industrial manufacturing setting, you will support day-to-day lab activities, including formulation and blending work, coordinating tests, and preparing samples for dispatch. This is a fantastic opportunity to build practical lab skills while developing your knowledge in performance testing and analytical science. Youll also have the chance to collaborate across teams, helping you grow your communication and technical skills in a professional environment. Key Responsibilities Contribute to maintaining high health &...

Chemistry Laboratory Technician (Operator) 24-25k South East ABJ6515 TEMP - 6 months – on site An excellent opportunity for an early-career Chemistry Laboratory Technician / Lab Operator to join a dynamic and supportive team within a modern laboratory environment. As lab technician you will pl

Title: Technical Service Chemist Location: Cheshire East Salary: £36,000 - £40,000 (dependent on experience) Term: Permanent SRG are working with a market-leading materials manufacturer specialising in the development and production of advanced coated products for a range of industri

As anAnalytical Chemist, you will play a key role in both routine quality control and advanced method development, directly contributing to the design of experiments, troubleshooting, and complex problem solving. This role will focus on the analysis of chemistry from a variety of sources in support

Senior Analytical Chemist £c54k prorate. An exciting opportunity for an experienced Analytical Chemist to join a leading analytical research team focused on developing innovative analytical capabilities to support product development, scientific research, and regulatory requirements. As an experien

If you are looking to take the next step in your career in the Waste Management industry, you are encouraged to apply! Package Benefits: 24 days holiday + 8 banks Company Pension Well-being programme and Mental Health Support Early Friday Finish Free Breakfast On-site parking Regular company event

An exciting opportunity has arisen for an Analytical Chemist to join a growing international organisation at the forefront of specialty chemicals innovation. Analytical Chemist £Competitive + Bonus. Are you an Analytical Chemist looking to take the next step in your career with a global industry le

Development Chemist require based in West Yorkshire on a permanent basis. Requiring a degree in Chemistry (or similar), with recent and extensive experience in formulating products such as lubricants, oils, greases, coatings (other aligned industries considered). Title: Development Chemist Location

Ink Chemist (Plastisol & Water-Based Formulations).

Shift Analytical Chemist required on a permanent basis, based in North Cheshire. Recent and proven industrial experience using GC, HPLC and wet chemistry is required. Title: Shift Analytical Chemist Location: North Cheshire Salary: £32,084 + Shift Allowance (~£10,900) Term: Permanent

At Chemtech Environmental, we like to think of ourselves as an extension of your team the kind that adds value without adding hassle (and yes, the sample containers are free).We keep things simple, personal and practical, offering tailored solutions and responsive support through our network of reg

Our client is an independent, British paint manufacturer, committed to the socially and environmentally responsible production of high-quality paints of which are renowned for their paints depth of colour undertones that subtly change in different lights, providing real character and definition.The

They are currently seeking a proactive and detail-focused Development Chemist to join their expanding technical team. This is an exciting opportunity for a chemist with some years of industry experience to play a hands-on role in the development of liquid-based products. Working closely with cross-f

Title: New Product Development (NPD) Chemist Location: Cheshire East Salary: £40,000 - £46,000 (dependent on experience) Term: Permanent SRG are working with a highly successful company that develop and manufacture a range of specialist coated products. They are now seeking a New Pro

Mobile Chemist role involving travel to customer sites to identify, classify, and safely pack hazardous waste for a leading UK Hazardous Waste Management company.

This is a 52 week non-sessional post i.Monday - Thursday, 09:00-17:00.We are looking for a motivated early years support workers to join the team at Wallyford to help deliver high quality childcare.To work in support of early years 'staff by contributing towards the creation of a warm, friendly, saf

Kitchen Team Leader - United Kingdom.Stonegate Group is the UK’s largest operator of pubs, bars, and late-night venues, including Slug & Lettuce, Be At One, and Popworld, to name a few.We’re proud of our diverse portfolio and deeply committed to creating an inclusive culture that embraces indiv

Apply today to work as a Production Operative for our client, a leading pork processing facility based in Bugle, St Austell.Staffline is recruiting Production Operatives to join a range of production departments across the site.Whether you are looking for full-time or part-time work, this is a fanta

Hours: Part time & full time hours available.Are you looking for a job that has purpose, something that makes you feel like you are making a difference?.We are looking for incredible, caring and patient people to join our brilliant team and make a difference to the lives of people we support.Helping

Warehouse Operative Location: Didcot Pay: £13.Hours: Monday to Friday | 10:00am – 6:30pm Immediate Starts Available Pertemps are currently recruiting for Warehouse Operatives to join a busy and well-established client based in Didcot.This is an excellent opportunity to join a friendly t

As a Warehouse Operative, you will play a key role in ensuring the smooth running of day-to-day warehouse operations.You will be responsible for handling goods, supporting stock control, and in a chill warehouse environment working as part of a team to meet daily targets.Key Responsibilities *

Job Title: Warehouse Operative.Hours: Monday to Thursday: 9:00 am to 5:00 pm.Our client is a rapidly growing IT asset management company with a strong focus on sustainable technology and exciting plans for growth, they are seeking a motivated Warehouse Operative to join their dynamic team.This role

Morning and Afternoon Shift Warehouse Logistics Operative.Immediate Start | MondayFriday | 6am to 2pm and 2pm to 10pm.Looking for a role where youre valued, supported, and given room to grow? Step into a future-focused logistics operation that pairs exceptional structure with a culture built around

Warehouse Operatives vacancies available – 6 Week Project Immediate start on Tuesday 21st July 2026 | Monday to Friday | No experience required | Join a friendly team on an important warehouse project Looking for a short-term role with full-time hours? We're recruiting Warehouse Operativ

Pertemps are currently recruiting a Warehouse Operative for our customer based in Hykeham, near Lincoln.We are looking for someone to work within our customers returns department, where you will be responsible for checking returned items and processing them accordingly.This role involves manual hand

Warehouse Operative Nightshift (Counterbalance FLT).Join a Market-Leading Distribution Business.Our client is one of the UK's leading distributors of thermoplastic sheet, rod and tubing, supplying customers throughout the fabrication, engineering and signage industries.Backed by a globally recognis

Warehouse / Logistics Operative.Full time, Permanent (Monday to Friday).Rotating 3 shift pattern 7am-4pm, 8am-5pm & 10am-7pm (a week of each).In this hands-on Logistics position, you will be joining an established team of operatives to pick, transport and receive materials and deliver them to the pr

The Recruitment Group is hiring!.We're on the lookout for a Warehouse Operative to join our well-established client based in Abingdon.Warehouse team on a temporary basis.OverallPurpose of the role will be to support the warehouse team leader in managing all warehouse activities.Need to be physically

Warehouse / Logistics Operative.Didcot Quarter (Near Milton Park) Abingdon Oxfordshire.Full time, Permanent (Monday to Friday).In this hands-on Logistics position you will be joining an established team of operatives and will be responsible for the safe handling of goods, parts and materials passing

Warehouse Operatives vacancies available – 6 Week Project Contract Immediate start on Tuesday 21st July 2026 | Monday to Friday | No experience required | Join a friendly team of six on an important warehouse project Looking for a short-term role with full-time hours? We're recruiting Wa

We're currently recruiting Order Pickers to join our team in Grantham.Job Details: - Location: Grantham - Role: Order Picker - Shift Pattern: Sunday to Thursday - Working Hours: 3:00pm – 11:30pm - Pay Rate: £15.Start Date: Monday 20th July Requirements: - Previous warehouse/or

M4 Specialist are recruiting for warehouse operatives in Didcot.Take delivery of warehouse items.M4 Specialist are an employment business and operates as an equal opportunities employer.Authority to issue an advertisement in respect of the above mentioned position has been obtained from the employer

Night Shift Warehouse Logistics Operative.Immediate Start | Sunday to Thursday | 10pm to 6am.Looking for a role where youre valued, supported, and given room to grow? Step into a future-focused logistics operation that pairs exceptional structure with a culture built around your success, wellbeing,

Our client, a reputable manufacturing company is hiring a dedicated Production Operative to join their team in South Oxford.This is a fantastic opportunity to contribute to the build, test, and inspection of high-quality products in a supportive and safety-conscious environment.What you'll be do

As a Day shift Warehouse Operative, you will be responsible mainly for training of couriers so they are able to effectively complete deliveries of parcels on set routes, by assisting with the training on the app that they require to use.With this, IT skills are essential.There are many other duties

We are currently seeking a Warehouse Operative to join our thriving team at Anglian Home Improvements, a leading provider of home improvement solutions.As a Warehouse Operative, you will play a vital role in the preparing of products for collection by the Installers and Service Engineers, and workin

We are pleased to announce we are recruiting Support Workers to join our passionate care team in the heart of Oxfordshire.We are looking to recruit vibrant, energetic, and motivated Support Workers to work at our supported living service in Headington, Oxfordshire.Here we provide quality person-cent

Job Title: Children’s Residential Support Worker Location: Witney, Oxfordshire Salary: £31,480 to £34,485 (Inclusive of sleep-ins) Are you passionate about making a positive difference in the lives of children and young people? A leading specialist provider is seeking dedicated Ma

We are looking for friendly, caring, and engaging people to be a part of our dedicated team at Headington, Oxfordshire.Working weekend shifts, you will support people with daily living activities and to live their best lives.Our supported living service supports people with learning disabilities, ph

Are you a Support Worker looking to make a meaningful difference? Join us at Transforming Support, where you'll help change lives and ensure quality care for those who need it most.Please note: Applicants must be authorised to work in the UK.We are unable to offer Visa sponsorships for this role.At

Job Title - Children's Residential Support Worker.Multiple Opportunities Across the West Midlands.Children's Residential recruitment.We partner with a carefully selected network of established children's residential providers across the West Midlands, helping passionate professionals find rewarding

Job Title: Care Assistant (Adult and Children's services) Location: West Sussex County Shifts: Monday to Sunday (Early Shift, Day Shift, Late Shift, Long Day, Waking Nights, Sleep-Ins) Salary: £13.We are recruiting for Care Assistants to support physically and/or mentally challenged child

Complex Care Support Worker - Stowmarket Job Description Clover Care Group is one of the UKs leading complex care providers and is regulated by the Care Quality Commission (CQC), the independent regulator of health and social care in England.Our regulated activity is the Treatment of Disease, Diso

Full-time | Part-time | Temporary (Ongoing).MedGen Healthcare is seeking compassionate, resilient, and dedicated.This role involves supporting children and adolescents with conditions such as.Autism Spectrum Disorder (ASD), ADHD, emotional and behavioural difficulties, and other additional needs.You

Help People Live Gloriously Ordinary Lives.At MacIntyre, we believe everyone deserves a life filled with friendship, choice, belonging and the freedom to enjoy the everyday moments that matter most.We're looking for caring, enthusiastic people to join our team and support people with learning and ph

Domiciliary Care Worker (Female Driver).Oxford, Bicester, Kidlington, Upper and Lower Heyford.Paid travel time between visits.Full Time and Part Time Opportunities Available.We are looking for compassionate and reliable Female Domiciliary Care Workers to join a growing home care team supporting peop