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\n Responsibilities\n The Opportunity to build a new Ophthalmology Precision Medicine function from the ground up — defining the vision, structure, and scientific direction for a group that integrates biomarkers, advanced imaging, clinical science, and AI across the pRED Ophthalmology portfolio. \n \n • Lead a cross‑functional expert team spanning translational medicine, imaging, clinical development, data science, and biomarker disciplines — ensuring precision medicine is at the heart of our Ophthalmology strategy.\n, • Bridge laboratory science and clinical practice by steering the generation of robust fluid‑ and imaging biomarker strategies that enable project and disease area decisions.\n, • Advance innovation in imaging science by directing cutting‑edge ophthalmic imaging approaches including OCT, OCT‑A, and FA to inform future clinical practice and therapeutic development.\n, • Enable translational insights through AI and data by integrating preclinical and clinical datasets using classical and next‑generation analytical approaches.\n, • Influence portfolio strategy across multiple retinal diseases including neovascular AMD, diabetic macular edema, geographic atrophy, and intermediate AMD — driving the direction and future of clinical development and research.\n, • Represent Roche externally through strong partnerships with scientific experts, investigators, and the broader ophthalmology community — remaining at the forefront of innovation.\n Qualifications\n \n, • Board‑certified ophthalmologist (MD or MD/PhD) with deep expertise in ophthalmology, translational medicine, or biomedical sciences.\n, • Recognised expert in the retina space, with a strong scientific publication record and standing as a key opinion leader in the field.\n, • Deep knowledge of ophthalmic imaging technologies (OCT, OCT‑A, FA) and experience with imaging analysis or Reading Centre environments.\n, • Experience in integrating preclinical and clinical data to support proof of biology, efficacy, and safety strategies, with some exposure to clinical trials.\n, • Collaborative scientific leader who thrives in matrix environments, energized by innovation and the opportunity to build something new.\n Preferred Experience\n \n, • Applying AI or machine learning to ophthalmic imaging analysis or clinical data interpretation.\n, • Prior experience in pharmaceutical drug development programmes for retinal diseases.\n Other Information\n Flexible working arrangements may be available for exceptional candidates who wish to maintain some clinical activity alongside this role. \n If building a world‑class precision medicine function and shaping the future of ophthalmic therapy development is the kind of challenge that excites you, apply now and help us bring transformative medicines to patients faster. \n The statements herein are intended to describe the general nature and level of work being performed by employees, and are not to be construed as an exhaustive list of responsibilities, duties, and skills required of personnel so classified. Furthermore, they do not establish a contract for employment and are subject to change at the discretion of Roche Products Ltd. At Roche Products we believe diversity drives innovation and we are committed to building a diverse and flexible working environment. All qualified applicants will receive consideration for employment without regard to race, religion or belief, sex, gender reassignment, sexual orientation, marriage and civil partnership, pregnancy and maternity, disability or age. We recognise the importance of flexible working and will review all applicants’ requests with care. At Roche difference is valued and we are proud to be an equal opportunity employer where you are encouraged to bring your whole self to work. \n #J-18808-Ljbffr

Day Webster are currently recruiting for an experienced Locum Consultant Child and Adolescent Psychiatrist in Eating Disorders in Watford. Essential Experience of the full range of clinical responsibilities expected of a consultant in child and adolescent service. Experience of close collaborative working with social care and other agencies Experience of working with service users who have complex needs within child and adolescent service. Excellent clinical skills using bio-psychosocial perspective and wide medical knowledge. Excellent oral and written communication skills. Able to manage clinical complexity and uncertainty. Makes decisions based on evidence and experience including the contribution of others. What you need – Role requirements AC and Sec 12 essential CAMHS and Eating Disorders experience required GMC registration Day Webster Group currently have positions throughout the United Kingdon, Channel Islands, and Republic of Ireland for Psychological Therapies professionals of all Bands between 3 – 8c; If this isn’t the right role for you and you would be eager to speak to a Specialist Industry expert to discuss your personal requirements and further roles available, contact the team at (url removed) or on (phone number removed). Why work for Day Webster Group? Daily payroll Access to some of the UK’s most sought-after roles Timesheet submissions via Mobile Specialist Industry expert as your dedicated Day Webster Agent available 24/7 Industry leading fast-tracked compliance Free revalidation support UK leading referral programs Accommodation & Travel assistance Annual contributions for training and CPD courses Annual Loyalty reward programs Professional growth opportunities and continuous development support. Uncapped top tier “Refer a friend” scheme. About Day Webster Group As one of the UK’s largest healthcare recruitment agencies, Day Webster Group are not only about filling positions; we're about building careers and fostering a community of professionals dedicated to excellence in healthcare. Since 2009, Day Webster Group has stood out for our innovative approach, earning numerous awards, including placements on The Sunday Times Fast Track 100 list and regional Best Companies to Work For. Recognised for our commitment to excellence and our deep appreciation for the vital roles our staff play, we support our team members at every step, offering opportunities for those looking for new challenges or aiming to make a significant impact in various healthcare settings

We are proud to be actively recruiting for an excellent Primary Academy School on the borders of St. Albans for a Reception Teacher. We are looking for an experienced teacher able to successfully deliver the Early Years Foundation curriculum, observe, assess and confidently plan engaging lessons to their pupils. \n At this 2-form entry school the children are at the centre of everything. The school believe that their children learn best when they are interested, inquisitive and engaged. The school are keen to appoint a teacher who has a real passion for teaching. \n The school aim to recruit a qualified Reception Teacher who can build positive relationships, create a supportive atmosphere, building resilience and encouraging children to share their feelings. \n Position: Reception Teacher. \n Start Date: September \n Contract: Perm, following main pay scale from MPS3 to MPS6 depending on experience \n Location: St. Albans \n The school strive to ensure every child is able to meet their full potential and is ready for the next phase of education by providing a rich and deep curriculum. This is an inclusive school who provide excellent learning opportunities and a stimulating learning environment which meet the needs of each individual child and promotes a lifelong love of learning. \n The school and Academics wish to appoint an excellent Reception teacher who: \n\n • Is passionate about making a difference to all children.\n, • Cable of building strong relationships with children, families and colleagues.\n, • Has high expectations of pupils' achievement and attitudes to learning.\n, • Qualified Teacher Status\n, • Capble of travelling to and from St. Albans on a daily basis.\n\n If you chose to join this excellent school, the school promise to offer: \n\n • Exceptional CPD with subject leadership\n, • Career progression opportunities internally or across the Trust.\n, • A supportive work environment with a Trust that understands the importance of enhancing health and wellbeing at work\n, • A generous pension and annual leave entitlement\n, • Inclusive policies and practices\n, • Well-behaved and enthusiastic children.\n, • Strong links with the community and local church groups\n\n If you are keen to find out more about this opportunity in St. Albans, then please get in touch with our Berkhamsted office who are actively working this vacancy. Please quote "Reception Teacher, St. Albans"

Senior Site EngineerSix-Month Fixed Term Contract£50,000 to £65,000Northern Home CountiesOverviewA Senior Site Engineer is required for a six-month fixed-term contract within the Northern Home Counties business unit, working with a Tier 1 Contractor. The role will support delivery on two major schemes initially before moving onto one project. This is a site-based position suited to an engineer with strong technical capability and experience in complex structures, including CAT 3 basement works.About the RoleThe Senior Site Engineer will support the Project Team with day-to-day engineering duties and ensure all works are delivered in line with client requirements. Responsibilities include interpreting drawings and specifications, checking setting out, monitoring retained structures, managing deep excavations and overseeing cut and fill modelling. The role also covers stabilisation checks, piling tolerance recording and inspections of reinforced concrete elements.The Senior Site Engineer will provide technical information to support commercial review of subcontractor analysis, report any survey deviations to the Project or Contracts Manager and maintain all required systems and procedures. The position requires strong awareness of health and safety standards, accurate record keeping and proactive engagement with the changing status of the project. The Senior Site Engineer will also support method statement approval, compliance monitoring and provide technical advice to the wider team.Experience RequiredExperience delivering complex structural worksExperience of a CAT 3 basement buildStrong understanding of construction techniques and sequencingExperience working on large scale schemesWhat We Are Looking ForA Senior Site Engineer with a solid technical background, strong communication skills and the ability to work collaboratively within a busy project team. A CSCS card is required, with SMSTS or SSSTS preferred. The successful candidate will be committed, organised and able to maintain high standards of quality, safety and delivery.Whats On OfferA six month fixed term contract within a supportive and inclusive team environment. The Northern Home Counties business unit offers a varied workload, exposure to major projects and the opportunity to contribute to high profile schemes. The team culture is collaborative, supportive and focused on delivering high quality work with consistency and professionalism.TPBN1_UKTJ

We are looking for a highly capable Data Architect to join us on a 24-month FTC, bringing the ability to translate business needs into robust, scalable data architectures and confidently lead end-to-end design across complex, multi-domain technology landscapes.The role requires someone who can work collaboratively with business stakeholders, solution architects, data engineers, and product teams to shape, govern, and deliver scalable, reliable, and data-driven solutions that support operational, analytical, and regulatory objectives, while embedding integrity, lineage, and governance throughout the wider data estate and ensuring alignment to enterprise architecture and strategy.The ideal candidate will bring strong expertise in conceptual, logical, and physical data modelling, alongside deep experience in data governance, data quality, and metadata management. A strong knowledge of Master and Reference Data Management (MDM/RDM), with experience working across integrated data governance and metadata management ecosystems, including Infosphere, Alation, Informatica, and Ataccama, supporting data quality, lineage, governance, and enterprise-wide data consistency, would be highly valuable.Key ResponsibilitiesData Architecture & ModellingDevelop conceptual, logical, and physical data models for operational, analytical, and regulatory workloads.Create and maintain data architecture blueprints and reference architectures covering ingestion, integration, storage, lineage, and consumption.Define modelling patterns (3NF, dimensional/star, Data Vault, canonical models) and guide teams on when and how to apply them.Optimise physical designs for performance, scalability, cost and resilience across cloud data platforms (e.g., Snowflake, Databricks, Synapse, BigQuery).Lead design reviews, ensuring models are accurate, high-quality, and aligned with business capabilities and domain boundaries.Data Governance & Metadata ManagementDefine data ownership, stewardship models, and contribute to the governance operating framework.Build and maintain data dictionaries, business glossaries, critical data elements (CDEs) and metadata standards.Ensure all data solutions align with governance policies, including lineage, retention, access, and security requirements.Support governance forums and collaborate with business stewards to drive consistent definitions and controlled change.Data Quality Architecture & PipelinesEmbed data quality rules and dimensions (completeness, timeliness, accuracy, uniqueness, validity, consistency) across ETL/ELT and streaming pipelines.Design data quality metrics, alerts, and monitoring frameworks to surface quality issues to stewards and downstream consumers.Partner with engineering teams to implement automated DQ checks, profiling, and remediation patterns.Ensure DQ scoring and lineage are built into architecture in a systematic and reusable way.Stakeholder Engagement & Requirements LeadershipLead architectural discovery to capture business needs, translate them into data requirements, and shape programme/solution scope.Manage and communicate architectural decisions with senior business and technical stakeholders.Navigate ambiguity and stakeholder nuance, ensuring alignment across product teams, SMEs, vendors, and governance bodies.Produce high-quality design documentation and present designs to Architecture Review Boards or equivalent governance forums.Delivery Governance & Technical LeadershipOversee the implementation of data architectures and ensure engineering teams follow patterns, standards, and best practices.Provide technical guidance on integration design, ingestion patterns, transformation methods, caching, orchestration, and storage optimisation.Conduct design assurance throughout delivery, ensuring solutions adhere to non-functional requirements (performance, availability, resilience, cost).Coach engineers, analysts, and stewards on modelling, data quality, and governance practices.Skills & Experience RequiredEssentialProven experience as a Data Architect, Solution Architect with strong data background, or senior data engineer/analyst transitioning into architecture.Knowledge of Master and Reference Data Management and experience of integrated associated systems (Infosphere, Alation, Informatica, Ataccama etc)Demonstrable expertise in conceptual, logical, and physical data modelling with clear understanding of modelling patterns and trade-offs.Strong understanding of data governance frameworks, metadata management, data ownership/stewardship models, and business glossaries.Hands-on experience embedding data quality rules, profiling, scoring, and exception management into pipelines.Familiarity with modern cloud data platforms (Snowflake, Databricks, Azure Synapse, BigQuery, Redshift, etc.).Ability to lead architectural thinking across multiple domains and manage stakeholder complexity.Ability to produce high-quality architectural artefacts: blueprints, models, solution designs, integration specifications.Experience working in regulated sectors (utilities, financial services, health, etc.) is advantageous.DesirableExperience with data mesh, domain-driven design, or federated data ownership models.Experience with Great Expectations, dbt tests, or enterprise DQ tooling.Knowledge of MDM, reference data management, and semantic modelling.Experience with streaming platforms (Kafka, EventHub) and API-based integration.Understanding of AI/ML data preparation pipelines and feature store design.What Success Looks Like in This RoleClear, scalable data models adopted across teams and projects.High trust and alignment among stakeholders because architectural decisions are well-reasoned and clearly communicated.Measurable improvements in data quality, lineage visibility, and governance adoption.Production of repeatable design patterns and frameworks that accelerate delivery.Delivery teams are confident, aligned, and able to execute effectively because the architecture removes ambiguity.Why Join Us?Work at the centre of a major transformation in a sector where reliable data is mission-critical.Influence enterprise-level data strategy and shape how data is governed, modelled, and used across the organisation.Join a team that values architectural thinking, collaboration, transparency, and continuous learning.Opportunity to work across diverse data domains including asset management, customer operations, leakage, regulatory reporting, and sustainability.Benefits:Competitive salary dependant on skills and experienceLearning and development opportunities, including mentoring and a range of formal courses and open learning resources.Entry into the company annual bonus scheme.Annual leave from 26-30 rising with length of service, and the option to purchase up to 5 extra days.A Celebration Day in addition to public holidays that people can use to celebrate a religious festival or other occasion that is important to them.A generous 'double match pension scheme' that doubles the contributions you make (company contribution capped at 12%)We offer a range of family benefits including enhanced Maternity, Adoption, Paternity, Shared Parental Leave, Fertility Support Leave and up to 5 full or 10 half days of paid Carers Leave.Menopause policy and Reasonable Adjustment policy to help everyone perform at their best.Access to our Wellbeing Centre with support for looking after your physical and mental health.Discounts at a Range of Retail Outlets through our Tap4Perks schemeDiscounts on Dental and Medical Insurance through our Tap4Perks scheme through salary sacrificeUp to 4 Affinity days a year to volunteer in the community.Life Assurance.Disability Confident As a Disability Confident employer, were committed to offering interviews to disabled candidates who meet the essential criteria and opt in on the application form. Ask the Talent Acquisition lead for the full job description to see all the criteria. If we have a very high volume of applicants and were not able to offer interviews to all, well take a fair and proportionate number of disabled candidates through.Affinity Water recognises the benefits of greater diversity in our workforce to better reflect the communities we serve. We are committed to building a more inclusive culture where every member of our workforce can thrive.TPBN1_UKTJ

The Company We are partnering with one of the UK’s most respected main contractors, a business with a turnover exceeding £700 million and a strong national presence. Over the past 25 years, they have built deep, long-standing client relationships, resulting in a substantial secured order book and a healthy pipeline of projects nationwide. This opportunity sits within a well-established business unit delivering refurbishment, remediation, retrofit, and building safety projects across London and the South. Their client base includes local authorities and housing associations, with schemes spanning residential, student accommodation, and wider regeneration programmes. You'll be joining a business led by a highly experienced senior leadership team with a proven track record of delivering complex, high-quality projects. The culture is collaborative, stable, and built around long-term frameworks rather than one-off wins. The Role - Senior Quantity Surveyor - Hybrid As Senior Quantity Surveyor, you will play a key role in the commercial delivery of a portfolio of projects across London and the South, with a primary focus on fire remediation, retrofit, planned maintenance, and refurbishment schemes delivered on behalf of Housing Associations and Local Authority clients. Working within a well-established business unit, you will be involved in the commercial management of projects ranging from building safety and cladding remediation works through to decarbonisation, internal and external refurbishment, and planned maintenance programmes. These projects are delivered through long-term frameworks and repeat client relationships, offering both stability and a consistent pipeline of work. Reporting to the Commercial Manager, you will take responsibility for all commercial aspects of your projects, ensuring they are delivered profitably while maintaining excellent client and stakeholder relationships. Key Responsibilities Managing the commercial and contractual aspects of fire remediation, retrofit, planned maintenance, and refurbishment projects from inception through to final account. Producing accurate cost forecasts, CVRs, budgets, and monthly financial reports. Procuring and managing subcontractor packages, including valuations, payments, and final accounts. Administering change control procedures and managing variations effectively. Ensuring contractual compliance and managing risk across multiple projects. Supporting operational teams to maximise project performance and profitability. Building strong working relationships with Housing Association and Local Authority clients. Identifying commercial opportunities and implementing best practice cost management. Contributing to monthly commercial reviews and supporting the wider commercial team. About You Proven experience as a Quantity Surveyor or Senior Quantity Surveyor within a main contractor environment. Strong background delivering social housing, planned maintenance, refurbishment, retrofit, building safety, or fire remediation projects. Experience working with Housing Associations and Local Authority clients would be highly advantageous. Strong knowledge of JCT contracts and commercial management processes. Excellent communication, negotiation, and stakeholder management skills. Ability to manage multiple projects and work autonomously. Relevant construction-related qualification (Degree, HNC, HND, or equivalent). What's on Offer Join a £700m+ turnover contractor with a substantial secured order book and long-term pipeline of work. Opportunity to work on meaningful building safety, fire remediation, and regeneration schemes that positively impact local communities. Stable workflow through long-term frameworks with Housing Associations and Local Authorities. Supportive senior leadership team and collaborative culture. Excellent career progression opportunities within a growing and successful business unit. Competitive salary, car allowance, bonus, and comprehensive benefits package

Roche in Welwyn is seeking a board-certified ophthalmologist to establish an Ophthalmology Precision Medicine group. This dynamic role will define vision and scientific direction, integrating biomarkers, imaging, and AI to transform retinal disease treatment. The ideal candidate has deep expertise in ophthalmology and scientific leadership skills, with a strong publication record. This is a unique opportunity to shape the future of precision medicine. #J-18808-Ljbffr

As the Global Head of Biostatistics, you will provide strategic leadership and oversight across all Therapeutic Area (TA)-aligned Biostatistics teams, ensuring a cohesive and high-performing Biostatistics function that drives excellence in service of our strategy through study design, data analysis, and insights generation. You will report to the Global Head, PD Data Sciences & Analytics (PD-DSA), and you will be responsible for shaping the Biostatistics strategy across all therapeutic areas in alignment with broader PD-DSA and company objectives, as well as your organization’s overall performance. Your role will be instrumental in advancing innovative statistical methodologies, fostering collaboration across internal and external stakeholders, and ensuring the highest scientific rigor in all statistical activities. You will lead a global, high-performing organization of approximately 100‑125 Biostatistics professionals focused on late-stage development. Your direct reports will be a team of five therapeutic area–aligned Biostatistics Leaders. Sitting on the PD-DSA leadership team, you will collaborate with senior leaders in PD-DSA and beyond to influence and contribute to the overall strategy and success of late‑stage development programs at Roche. • Develop and set a clear PD-DSA strategy and goals that align with Roche’s broader objectives, ensuring that you integrate Roche’s One Pharma strategy, PD goals, and R&D Excellence methods into the strategic direction., • Embed and drive the adoption of PD-DSA’s strategic imperatives of Data, Digital/AI, and Design (the 3Ds) across your teams’ workflows, taking ownership of this mindset shift to ensure a seamless integration of these principles into daily operations., • Act as a role model for your teams by delivering excellence in all aspects of your work (what you do, how you do it, and the impact you have), fostering a culture of learning, growth, and continuous improvement that empowers team members to reach their potential., • Define and create clear accountability across each function in your organization and beyond, ensuring that you work in lock‑step with your colleagues and partners to maintain alignment and drive cross‑functional collaboration., • Provide strategic leadership and oversight across all five Therapeutic Area‑aligned Biostatistics leaders and their teams, ensuring a consistent and high‑quality approach to Biostatistics across all therapeutic areas., • Develop and implement a comprehensive Biostatistics strategy that aligns with Roche’s research and development objectives., • Ensure that biostatistical considerations are integrated early in study designs and development programs, aligning with regulatory and scientific best practices., • Partner closely with senior leadership across PD-DSA, clinical development, regulatory affairs, and data science teams to shape the future of statistical contributions within Roche., • Represent Biostatistics as a strategic function, influencing high‑level decision‑making and driving cross‑functional collaboration to optimize study designs and data strategies., • Evaluate challenges as they arise and develop innovative solutions for teams to execute., • Act as the primary liaison between the Biostatistics function and key stakeholders across Clinical, Regulatory, and Data Science teams to drive alignment and shape outcomes for shared objectives; connect key stakeholders with therapeutic area Biostatistics Leaders as nuanced questions arise., • Ensure seamless collaboration between Biostatistics and external partners, including regulatory agencies, academic institutions, and industry consortia., • Represent Roche in industry forums, regulatory discussions, and cross‑industry collaborations to influence and stay ahead of emerging biostatistics trends., • Align closely with the PD‑DSA‑led Innovation Council and broader AI strategy to ensure Biostatistics contributes meaningfully to the company’s digital and AI transformation initiatives., • Ensure the highest scientific rigor and adherence to regulatory standards in all statistical methodologies and study designs across therapeutic areas., • Champion the adoption of AI, digital, and advanced statistical methodologies to enhance study designs and improve efficiency in data analyses., • Oversee the prioritization and implementation of modern digital and AI capabilities in study design and statistical approaches., • Maintain and enforce compliance with industry regulations, GCP, and biostatistical best practices across all programs., • Lead, inspire, and develop a high‑performing global team of biostatistics leaders, ensuring their continued professional growth and ability to drive strategic impact., • Establish a strong culture of accountability, innovation, and continuous learning within the Biostatistics function., • Define clear performance metrics and success criteria for the Biostatistics function, ensuring alignment with organizational goals., • Partner with P&C and leadership to attract, retain, and develop top biostatistical talent to support long‑term organizational success., • PhD, or other advanced degree in Statistics, Biostatistics, or Mathematics., • More than 15 years experience (significant experience working at a senior level) in the pharmaceutical/biotech industry with an emphasis in molecule and molecule‑enabling strategy; ability to consult and understand medical issues., • In‑depth knowledge of Good Clinical Practice (GCP), international and in‑country regulations, guidelines and their application, and all other applicable compliance standards related to data and statistical sciences and industry conventions., • Thorough understanding of the end‑to‑end drug development lifecycle, particularly on elements involving data and statistical sciences, advanced analytics methods and data visualization tools and techniques., • Experience and understanding of the new trends with all relevant data types (e.g., high‑dimensional data) and analytics., • Track record of establishing successful internal and external partnerships with relevant partner organizations and ability to act as an ambassador for Roche., • Willingness to adopt new technologies and methodologies, deep interest in AI and digital advancements., • Influential and confident communicator., • Strong English language skills., • International travel as required – estimated at 20%. Relocation assistance is being offered for this position. • South San Francisco, CA, • Boston, MA, • Basel, Switzerland, • Welwyn, UK, • Mississauga, Canada The expected salary range for this position based on the primary location of South San Francisco, CA is $338,240 - $443,940. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. #J-18808-Ljbffr

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. Within Pharma Research & Early Development (pRED), our Ophthalmology teams are redefining how precision medicine can transform the detection and treatment of complex retinal diseases. This is a rare opportunity to build a new function from the ground up — establishing an Ophthalmology Precision Medicine group at our Welwyn site that brings together biomarker science, advanced imaging, clinical expertise, and artificial intelligence. You will have the platform, pipeline, and resources to shape something truly new in one of the most dynamic areas of ophthalmic research. • Build a new Ophthalmology Precision Medicine function from the ground up — defining the vision, structure, and scientific direction for a group that integrates biomarkers, advanced imaging, clinical science, and AI across the pRED Ophthalmology portfolio., • Lead a cross‑functional expert team spanning translational medicine, imaging, clinical development, data science, and biomarker disciplines — ensuring precision medicine is at the heart of our Ophthalmology strategy., • Bridge laboratory science and clinical practice by steering the generation of robust fluid‑ and imaging biomarker strategies that enable project and disease area decisions., • Advance innovation in imaging science by directing cutting‑edge ophthalmic imaging approaches including OCT, OCT‑A, and FA to inform future clinical practice and therapeutic development., • Enable translational insights through AI and data by integrating preclinical and clinical datasets using classical and next‑generation analytical approaches., • Influence portfolio strategy across multiple retinal diseases including neovascular AMD, diabetic macular edema, geographic atrophy, and intermediate AMD — driving the direction and future of clinical development and research., • Represent Roche externally through strong partnerships with scientific experts, investigators, and the broader ophthalmology community — remaining at the forefront of innovation., • You are a board‑certified ophthalmologist (MD or MD/PhD) with deep expertise in ophthalmology, translational medicine, or biomedical sciences., • You are a recognised expert in the retina space, with a strong scientific publication record and standing as a key opinion leader in your field., • You have deep knowledge of ophthalmic imaging technologies (OCT, OCT‑A, FA) and experience with imaging analysis or Reading Centre environments., • You are experienced in integrating preclinical and clinical data to support proof of biology, efficacy, and safety strategies, with some exposure to clinical trials., • You are a collaborative scientific leader who thrives in matrix environments, energised by innovation and the opportunity to build something new., • Experience applying AI or machine learning to ophthalmic imaging analysis or clinical data interpretation., • Prior experience in pharmaceutical drug development programmes for retinal diseases., • Flexible working arrangements may be available for exceptional candidates who wish to maintain some clinical activity alongside this role. If building a world‑class precision medicine function and shaping the future of ophthalmic therapy development is the kind of challenge that excites you — apply now and help us bring transformative medicines to patients faster. A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life‑changing healthcare solutions that make a global impact. Let’s build a healthier future, together. The statements herein are intended to describe the general nature and level of work being performed by employees, and are not to be construed as an exhaustive list of responsibilities, duties, and skills required of personnel so classified. Furthermore, they do not establish a contract for employment and are subject to change at the discretion of Roche Products Ltd. At Roche Products we believe diversity drives innovation and we are committed to building a diverse and flexible working environment. All qualified applicants will receive consideration for employment without regard to race, religion or belief, sex, gender reassignment, sexual orientation, marriage and civil partnership, pregnancy and maternity, disability or age. We recognise the importance of flexible working and will review all applicants’ requests with care. At Roche difference is valued and we are proud to be an equal opportunity employer where you are encouraged to bring your whole self to work. #J-18808-Ljbffr

Location: UK - Hatfield | Job-ID: 218725 | Contract type: Standard | Business Unit: Others Life on the team Are you a strategic Internal Audit leader who can combine governance excellence with commercial insight? Computacenter is looking for a Director of Internal Audit to join this fast-growing Internal Audit and Risk Management team. The Director of Internal Audit will provide independent assurance to the plc Board and senior management on the effectiveness of internal controls across the Group’s activities. The Director of Internal Audit will report to the Group Head of Internal Audit and Risk Management. This is a high-profile leadership role, with the opportunity to shape the future of the Internal Audit function, influence senior stakeholders, and play a key role in strengthening risk, control and governance across a complex international business. • Lead the continued evolution of the Internal Audit function, implementing change as the needs of the Group and professional standards develop, • Build strong partnerships across Computacenter, working closely with senior stakeholders and representing Internal Audit at management meetings, • Lead, coach and develop the Internal Audit team, creating a high-performance culture focused on quality, insight and continuous improvement, • Drive Computacenter’s response to Provision 29 of the UK Corporate Governance Code, ensuring a robust and effective controls framework, • Own the development and oversight of the annual risk-based Internal Audit plan, including quality assurance reviews of working papers and reports, • Provide clear, credible reporting to the Audit & Risk Committee, helping to shape effective decision‑making, • Commission and oversee the performance of third-party providers, ensuring high-quality delivery and alignment to the Group’s audit objectives., • Extensive experience leading Internal Audit functions within a large, complex global organisation, ideally within a FTSE 100/250 environment and/or gained through the Big Four / professional services., • A strong track record in internal controls and assurance, and a deep technical expertise in Internal Audit, with significant leadership experience., • The credibility and confidence to work with Audit Committees, Board-level stakeholders and senior leadership., • A proven ability to develop high‑performing teams and raise standards through coaching, challenge and continuous improvement., • A relevant professional qualification such as CA, MBA, ACCA, CPA, CIA or equivalent., • A strong understanding of internal and statutory audit, assurance practices and the requirements of the UK Corporate Governance Code., • Excellent communication, stakeholder management and presentation skills, with the ability to influence at all levels., • A collaborative leadership style, strong judgement and ethical compass., • Strong project management capability and the ability to work effectively across cultures., • Experience in a complex, international IT service or contracting business with an understanding of the key risks and challenges facing the industry., • Experience of auditing technology platforms, digital products and major transformation programmes., • Experience of AI governance and automation of audit practices. Computacenter is a leading independent provider of IT infrastructure services, with about 21,000 employees worldwide. We work at the heart of digitisation, advising organisations on IT strategy, implementing the most appropriate technology and managing our customers’ infrastructures. #J-18808-Ljbffr

MrQ - we're an awesome, award winning online casino launched in 2018. We're big on tech, big on performance and most of all - big on fun. Over the years, we have experienced explosive growth - which means we need more rock stars to join our quest for total world domination. This is a founding security engineering role. There is no existing function, no inherited tooling, no playbooks to follow while you're building it. We need someone who can own the entire security engineering discipline end to end: define the strategy, architect the solutions, deploy and manage the tooling, write the policies, run the operations, and report on posture to the business. You’ll work as a direct partner to the IT Ops Specialist. The two of you will shape how security and IT operations work together across the organisation. This means you need to be technically exceptional while also being the person who builds the governance, drives compliance, and ensures security has a seat at every strategic decision. You will own the security roadmap, influence technology and platform choices, and be accountable for the security posture of the business. This is not a support role, it’s a senior position that demands both engineering depth and strategic ownership • Strategic Ownership: Define and own the enterprise security strategy and multi-year roadmap. Identify gaps, set priorities, allocate effort and deliver. This feeds directly into business-level risk decisions., • Technical Authority: Be the definitive technical voice on security across the organisation. Evaluate threats, make architectural decisions, and set the standard for how security is implemented across every platform and system., • Partnership: Operate as a strategic partner to the IT Ops Specialist. Jointly shape how security and IT operations integrate shared tooling decisions, aligned processes, unified incident response, single view of risk., • Stakeholder Influence: Present security posture, risk appetite and investment cases to senior leadership. Translate technical risk into business impact. Ensure security is embedded into every major technology and product decision., • Security Stack: Evaluate, select, deploy, configure and manage the full enterprise security tooling suite from scratch — EDR/XDR (CrowdStrike/SentinelOne), SASE/SWG (Netskope/Zscaler), SIEM, email security, DLP, endpoint privilege management, application allowlisting., • Architecture: Design and implement enterprise security architecture built on zero trust and secure-by-default principles. Own the technical blueprint across cloud (AWS), SaaS, endpoints, network and identity., • Detection Engineering: Build, tune and maintain detection rules, correlation logic and alerting across SIEM and EDR. Engineer high-fidelity detections mapped to MITRE ATT&CK. Continuously reduce false positives and expand coverage., • Automation: Engineer automation for security operations at scale — scripting (Python, Bash, PowerShell) for response orchestration, access reviews, compliance checks, vulnerability reporting, threat intel enrichment., • Integration & Evaluation: Ensure all security tooling integrates with existing infrastructure and identity platforms. Lead POCs, vendor evaluations and build-vs-buy decisions for new security technologies., • IR Leadership: Own the full incident response lifecycle — detection, triage, containment, eradication, recovery, post-incident review. Author and maintain IR playbooks, runbooks and escalation procedures., • Threat Intelligence: Investigate security events, perform root cause analysis, and apply threat intelligence to improve defensive posture. Understand attacker TTPs and operationalise frameworks like MITRE ATT&CK and NIST CSF., • Vulnerability Management: Own the vulnerability management programme end to end — scanning, prioritisation, remediation tracking, SLA enforcement and executive reporting across infrastructure, endpoints and applications., • Application & API Security: Assess the security of internal applications, third-party integrations, APIs, payment flows and authentication systems. Identify both technical vulnerabilities and product-level abuse scenarios., • IAM & Zero Trust: Architect and enforce the identity strategy — SSO, MFA, SAML, OAuth, SCIM, conditional access, passwordless authentication. Design and enforce least-privilege and zero trust access policies across all systems., • Endpoint Security: Define and enforce endpoint security standards at scale — hardening, patching, disk encryption, MDM, device compliance. Own the endpoint security posture across the full macOS and Windows fleet., • Access Governance: Design and run access review and certification programmes. Proactively identify over-provisioned access, orphaned accounts, shadow IT and policy gaps. Maintain a clean, auditable access estate., • Build the Framework: Establish the security governance framework from the ground up policies, standards, procedures and controls aligned to ISO 27001, SOC 2, Cyber Essentials and GDPR. This function doesn’t exist yet; you’re creating it., • Audit & Compliance: Maintain continuous audit readiness. Own evidence collection, control testing, gap analysis and remediation tracking. Be the person who sits with auditors and delivers clear, documented, defensible answers., • Risk Management: Conduct threat modelling and risk assessments. Own the risk register, drive treatment plans, and report on residual risk to leadership. Ensure risk management is embedded into project and change processes., • Documentation: Build and maintain the full security documentation estate architecture diagrams, tool configurations, runbooks, incident reports, risk registers, process maps, policy library. Set the standard for what good documentation looks like., • Security Awareness: Own the security awareness programme — phishing simulations, training campaigns, onboarding security inductions, policy rollouts. Be the visible face of security across the business., • 6+ years in security engineering, enterprise security or security operations with demonstrated impact building or significantly maturing a security function, • Deep hands-on experience deploying, configuring, managing and troubleshooting enterprise security tooling — EDR/XDR, SASE/SWG, SIEM, DLP, email security, endpoint privilege management, MDM, • Expert-level knowledge of identity and access management SSO, SAML, OAuth, SCIM, conditional access, MFA, passwordless with proven zero trust implementation in production, • Led incident response investigations end to end — built playbooks, managed containment and drove remediation across real-world security incidents, • Strong scripting and automation capability (Python, Bash, PowerShell) applied to detection engineering, security operations and compliance automation, • Direct experience building security governance — writing policies, implementing controls, preparing for and leading audit engagements (ISO 27001, SOC 2, Cyber Essentials, GDPR), • Fluent in security frameworks and threat methodologies (MITRE ATT&CK, NIST CSF, CIS Controls, OWASP) with practical application, not just theoretical knowledge, • Experience securing cloud-native and SaaS-heavy environments (AWS preferred), • Strategic thinker who can define a roadmap, influence stakeholders and make security decisions that balance risk with business enablement, • Experience in iGaming, fintech or another heavily regulated industry with understanding of gaming regulatory frameworks and player data protection, • Background in application security, API security testing, secure SDLC or product security within a platform-based business, • Hands-on SIEM detection engineering — writing correlation rules, building dashboards, tuning alert logic at scale, • Experience with cloud security tooling (AWS GuardDuty, Security Hub, CloudTrail, Config), SSPM, CASB or DLP platforms, • Relevant senior certifications (CISSP, CISM, GIAC GSEC/GCIH/GCIA, CySA+, vendor-specific: CrowdStrike CCFA/CCFR, Netskope) or equivalent proven track record, • Experience mentoring engineers, building team capability or shaping security culture across an organisation At MrQ, we take pride in providing an array of fantastic benefits to our valued team members. Enjoy a competitive salary package that recognizes your hard work and dedication. Need some extra time off? We've got you covered with additional leave days, and we believe in celebrating life's special moments, including your birthday, with dedicated birthday leave. Family matters to us, too, which is why we offer a generous four-week parental leave. Your well-being is our priority, supported by international health and life insurance. Stay motivated with wellness incentives and seize opportunities for personal and professional growth with our growth allowance. Embrace a flexible working environment that caters to your needs, and join our friendly and multinational team, where collaboration and camaraderie flourish. At MrQ, we're committed to ensuring that your experience with us goes beyond just a job – it's a fulfilling journey with a supportive community. We are committed to fostering a workplace that values and celebrates diversity. We welcome individuals of all backgrounds and experiences, and we believe that a diverse and inclusive environment leads to innovation and success. We actively promote equal opportunities for all employees and strive to create a space where everyone's voices are heard and respected. Join us in our journey to build a truly inclusive workplace where every person can thrive and contribute to our collective success. To help our recruitment team work efficiently, please apply to the role that best matches your skills and experience. Our team will consider you for other similar roles as well! #J-18808-Ljbffr

As a Senior Security Engineer in Tesco’s Detection Engineering team, you will lead the technical design of security-first infrastructure and deliver high-impact engineering outcomes that protect a global retail ecosystem serving millions of customers. You will translate complex threat and risk signals into resilient, testable, and automated security capabilities across Tesco’s technology landscape. This role blends deep engineering leadership with a customer-first mindset: preventing disruption, safeguarding trust, and raising the bar on engineering quality across cyber defence. You will also mentor engineers and help shape an innovation agenda that strengthens Tesco’s ability to detect and withstand sophisticated cyber threats. • Design, build and deploy complex, high‑reliability security capabilities that offer proactive visibility into Tesco’s estate and materially reduce risk to customer services and operational continuity., • response integration), ensuring maintainable, scalable outcomes., • Champion secure, test‑driven engineering, including code quality, automated testing, peer review and repeatable delivery practices across the team., • Identify opportunities and pilot AI-assisted and automation-driven approaches that improve detection lifecycle effectiveness (e.g., faster development, tuning, and quality assurance), ensuring changes deliver measurable improvements rather than novelty, • Coach and support junior engineers, building confidence in modern development practices, problem-solving, and pragmatic security design decisions., • Work seamlessly with Security Operations, Threat Intelligence, platform teams and product/engineering stakeholders to deliver integrated defences—communicating clearly, influencing effectively, and fostering an inclusive, high‑performing culture., • and how to deliver production-grade solutions safely (from design through build, test, deploy, operate and improve)., • with evidence of writing clean, maintainable code or scripts and applying appropriate patterns for reliability, scalability, and operational support., • with evidence of having developed custom detections and familiarity on working with data in an at-scale product., • (threat‑aware design, secure defaults, automated tests, and disciplined change control) and how these practices raise the quality bar across a team., • and how they underpin detection and response outcomes (e.g., telemetry sources, detection platforms, triage workflows, and response integration)., • fundamentals at scale—how to convert hypotheses about adversary behaviour into effective detections, how to reduce noise without impacting visibility, and how to sustain quality over time., • evidence of curiosity, continuous learning, and proactive professional development, including sharing knowledge and improving team practice., • proven ability to foster an environment where diverse perspectives are welcomed, engineers are supported, and collaboration is the default., • exposure to evaluating emerging techniques (including AI‑assisted approaches) with sound judgement—balancing value, safety, and operational reality., • Exposure to a core technology landscape and strong retail technology awareness, including how customer journeys and store/online operations shape risk., • Demonstrable understanding of security evaluation and functionality testing, including validating controls and detections against expected outcomes., • Cloud & container security knowledge, including common control patterns and engineering approaches to hardening cloud‑native services., • Applied AI for cyber defence familiarity (e.g., AI-assisted engineering, triage support, enrichment), and awareness of AI governance / responsible AI considerations., • Strong research habits and data‑informed decision making (using insights to tune detections, prioritise engineering effort, and quantify improvements)., • Experience working with delivery and operational tooling such as GitHub & Jira, and incident collaboration tooling such as Zendesk & xMatters., • Experience with a querying language such as SPL, KQL, SQL etc. in a Security Environment., • Communication and influencing skills across engineering, product and security stakeholders; comfort guiding decisions under ambiguity and driving change., • Familiarity with product methodologies and security architecture concepts to help shape “secure‑by‑design” outcomes across teams. We’re all about the little helps. That’s why we make sure our Tesco colleague benefits package takes care of you – both in and out of work. Click Hereto find out more! • Annual bonus scheme of up to 20% of base salary., • Holiday starting at 25 days plus a personal day (plus Bank holidays)., • Private medical insurance., • 26 weeks maternity and adoption leave (12 months service required at the qualifying date) at full pay, followed by 13 weeks of Statutory Maternity Pay or Statutory Adoption Pay, we also offer 6 weeks fully paid paternity leave., • Free 24/7 virtual GP service, Employee Assistance Programme (EAP) for you and your family, free access to a range of experts to support your mental wellbeing., • This information is a shortened summary, refer to our policies for full details. You might know us as a supermarket, technology company or even for our award‑winning mobile network. Truth is, we’re all of those things, and much more. Our colleagues work with one goal in mind, helping to make every day a little better for our customers, colleagues and communities all over the world. No two customers are the same, neither are our colleagues. At Tesco, we champion a balance that lets you thrive both in and out of work. Spend 60% of your week collaborating with colleagues at our office locations or local sites and the rest remotely. Whether you're just kicking off your career, juggling passions, or navigating big life events, we're here to support you. We always welcome a conversation about flexible working, so talk to us throughout your application about how we can support. We're proud to be an accredited Disability Confident Leader, where everyone’s welcome. That’s why we commit to providing a fully inclusive and accessible recruitment process. If you need support with your application,click herefor more information. And if you're interested in joining our team but don't tick every box, don't let that hold you back from applying. #J-18808-Ljbffr

F. Hoffmann-La Roche Gruppe in Welwyn is seeking a board-certified ophthalmologist to lead the Ophthalmology Precision Medicine group. This role involves building a new function and integrating innovative imaging technologies and AI to transform retinal disease treatment. The ideal candidate will have deep expertise in ophthalmology, a scientific publication record, and experience in clinical data integration. Join Roche to help shape the future of ophthalmic therapy development. #J-18808-Ljbffr

Tesco is seeking a Senior Security Engineer in the Detection Engineering team to lead the technical design of security-first infrastructure and deliver high-impact engineering outcomes that protect a global retail ecosystem serving millions of customers. You will translate complex threat signals into resilient, automated security capabilities across Tesco’s technology landscape. This role blends deep engineering leadership with a customer-first mindset: preventing disruption, safeguarding trust, #J-18808-Ljbffr

Technical Services Lead - Automotive Aftermarket Ideal backgrounds: Senior Technical Advisor, Technical Support Lead, Product Data Specialist, Catalogue Manager, Technical Support Team Leader (Automotive Aftermarket) A superb opportunity for an experienced automotive aftermarket technical specialist to step into a broader role supporting and guiding a small technical team within a respected aftermarket brand. This position blends deep product and application knowledge with cataloguing accuracy, range management, and cross‑functional collaboration - ideal for someone who already understands the aftermarket ecosystem and is ready to progress. You'll be central to maintaining accurate product and application data, supporting complex technical enquiries, and ensuring the integrity of cataloguing across UK and EMEA systems. Working closely with Sales, Marketing, Supply Chain and wider technical colleagues, you'll help deliver a technically robust, well‑supported product offering to the aftermarket. What's in It for You • Competitive salary Excellent benefits package including enhanced pension, private medical and 25 days holiday Excellent training and development opportunities Hybrid working (3 days in the office) with occasional UK travel A genuine step‑up role for an aftermarket technical specialist Location Commutable locations include St Albans, Watford, Luton, Milton Keynes, Aylesbury, High Wycombe, Stevenage, Hitchin, Harpenden, Hatfield, Welwyn Garden City, Leighton Buzzard, Amersham, Rickmansworth. What We're Looking For • Automotive technical qualification or relevant engineering degree Proven automotive aftermarket experience - ideally from a parts manufacturer, supplier, motor factor, or technical support environment Strong understanding of product application data, cataloguing standards, TecDoc, MAM, Autocat or similar systems Hands‑on knowledge of ignition, engine management or electronic components Experience analysing technical enquiries, warranty trends or product performance data Excellent attention to detail with a structured, methodical approach Ability to coordinate workload and support a small technical team Confident communicator able to collaborate across Sales, Marketing, Supply Chain and EMEA teams Understanding of warranty processes, quality control and product validation * Comfortable attending exhibitions, seminars and customer events when required What You'll Be Doing • Support the coordination and day‑to‑day guidance of the Technical Services team Maintain and improve product application databases, ensuring accuracy across UK and EMEA systems Assist with the creation of technical content, bulletins and product information for new ranges Monitor range coverage, ensuring catalogues and technical data remain up to date Track technical enquiries, analyse call log trends and recommend corrective actions Support the processing of warranty and damaged product returns, identifying root causes Work collaboratively with Sales, Marketing, Supply Chain and Technical teams to deliver a complete product and service offering Attend exhibitions, seminars, PR events and customer activities as required Build strong relationships with internal teams, external customers and third‑party data partners About the Company A well‑established and respected name in the automotive aftermarket, known for technical excellence, product quality and a collaborative culture. You'll join a team that values accuracy, continuous improvement and strong technical foundations. Register Your Interest Job Reference: 4354KBA - Technical Services Lead - Automotive Aftermarket Glen Callum Associates specialises in automotive recruitment, connecting exceptional talent with leading organisations across the aftermarket and aligned sectors. We welcome applications from all qualified candidates and are committed to fostering diverse and inclusive workplaces. If you require adjustments during the recruitment process, we're here to support you. Please note we are unable to offer sponsorship for this role.

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