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Senior Director, Medicinal ChemistryApplylocations: Oxford, United Kingdomtime type: Full timeposted on: Posted Todaytime left to apply: End Date: August 14, 2026 (24 days left to apply)job requisition id: REQ-29648Job DescriptionGENERAL SUMMARY:We are seeking a highly motivated and experienced Medicinal Chemistry leader to join our group at Vertex Oxford at the Senior Director level. Reporting to the Head of Medicinal Chemistry, you will lead a highly skilled and motivated medicinal chemistry team to discover high quality clinical candidates that progress into clinical trials. You will have a track record of success across multiple projects from Hit ID to Candidate delivery. You will lead, develop, and implement state of the art medicinal chemistry strategies, providing key expertise in medicinal chemistry and related disciplines (DMPK, biology, computational chemistry, process chemistry). You will help drive the development of our internal talent through continuous teaching and mentorship.You may also take on wider project leadership responsibility, driving a multi-disciplinary project team, accountable to the Site Head for the overall strategy and delivery of a key project within our portfolio.KEY RESPONSIBILITIES: Drive state of the art chemistry design and synthesis to rapidly deliver high-quality clinical candidates. Exercise exceptional judgement based on significant medicinal chemistry experience to ensure your team delivers molecules with low predicted human doses and overall profiles that enable rapid progression through pre-clinical safety assessments and into clinical trials Drive and motivate your team of medicinal chemists to deliver molecules using efficient synthetic routes, ensuring smooth transition to scale up teams to enable rapid progress and delivery to project goal timelines. Provide dynamic leadership of a multidisciplinary drug-discovery team working on a key project within our portfolio.SKILLS & EXPEREINCE: Qualifications in Organic or Medicinal Chemistry with extensive experience working in a pharmaceutical and/or biotechnology setting as a medicinal chemist. Leadership of medicinal chemistry teams with a strong record of scientific accomplishment and success delivering clinical candidates. Experience from Hit ID to candidate delivery, with deep knowledge of both molecular properties and drug substance solid form. Expert knowledge of medicinal chemistry literature, organic synthesis, and methodology, with good working knowledge of DMPK, biology, computational chemistry, and structure-based drug design. A concise and effective communication style to provide teams with clear guidelines, energy, drive, and motivation. Strong interpersonal teamwork and organizational skills, with ability to thrive in a dynamic, fast-paced, innovative environment. Ability to manage timelines and drive projects to rapidly answer key questions.Flex Designation:On-Site DesignatedFlex Eligibility Status:In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.#LI-OnsiteCompany InformationVertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com### About Vertex## Help Us Achieve Our Mission## Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency *.Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on Facebook,* Twitter/X *, LinkedIn, YouTube and Instagram.The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives.*Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work. #J-18808-Ljbffr

\n GENERAL SUMMARY\n We are seeking a highly motivated and experienced Medicinal Chemistry leader to join our group at Vertex Oxford at the Senior Director level. Reporting to the Head of Medicinal Chemistry, you will lead a highly skilled and motivated medicinal chemistry team to discover high quality clinical candidates that progress into clinical trials. \n You will have a track record of success across multiple projects from Hit ID to Candidate delivery. You will lead, develop, and implement state‑of‑the‑art medicinal chemistry strategies, providing key expertise in medicinal chemistry and related disciplines (DMPK, biology, computational chemistry, process chemistry). \n You will help drive the development of our internal talent through continuous teaching and mentorship. You may also take on wider project leadership responsibility, driving a multi‑disciplinary project team, accountable to the Site Head for the overall strategy and delivery of a key project within our portfolio. KEY RESPONSIBILITIES\n \n • Drive state‑of‑the‑art chemistry design and synthesis to rapidly deliver high‑quality clinical candidates.\n, • Exercise exceptional judgement based on significant medicinal chemistry experience to ensure your team delivers molecules with low predicted human doses and overall profiles that enable rapid progression through pre‑clinical safety assessments and into clinical trials.\n, • Drive and motivate your team of medicinal chemists to deliver molecules using efficient synthetic routes, ensuring smooth transition to scale‑up teams to enable rapid progress and delivery to project goal timelines.\n, • Provide dynamic leadership of a multidisciplinary drug‑discovery team working on a key project within our portfolio.\n SKILLS & EXPERIENCE\n \n, • Qualifications in Organic or Medicinal Chemistry with extensive experience working in a pharmaceutical and/or biotechnology setting as a medicinal chemist.\n, • Leadership of medicinal chemistry teams with a strong record of scientific accomplishment and success delivering clinical candidates.\n, • Experience from Hit ID to candidate delivery, with deep knowledge of both molecular properties and drug substance solid form.\n, • Expert knowledge of medicinal chemistry literature, organic synthesis, and methodology, with good working knowledge of DMPK, biology, computational chemistry, and structure‑based drug design.\n, • A concise and effective communication style to provide teams with clear guidelines, energy, drive, and motivation.\n, • Strong interpersonal teamwork and organizational skills, with ability to thrive in a dynamic, fast‑paced, innovative environment.\n, • Ability to manage timelines and drive projects to rapidly answer key questions.\n Flex Designation / Eligibility Status\n On‑Site Designated Flex Eligibility Status: In this On‑Site designated role, you will work five days per week on‑site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. Equal Employment Opportunity Statement\n Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com. \n #J-18808-Ljbffr

At Notpla we’re at the leading edge of sustainable innovation, creating natural alternatives to single-use plastic packaging that’s carefully engineered to create a healthier planet. Founded on the belief that nature knows best, we’re an innovative, ideas and action-oriented scale-up who develop and manufacture uncompromisingly natural packaging solutions from seaweed and plants. The Edibles Category Owner will spearhead the strategic and operational success of the Edibles product line at Notpla. This category includes Ohoo, edible films, and pipettes, among other innovative products. This is an exciting time to join Notpla, right on the brink of a record-breaking year for revenue and on-track for major growth in the next 18-24 months. Bolstering confidence in our financial performance, we have just secured a Series A+ fundraise for £20million, enabling us to scale our growth and environmental impact faster than ever. The Category Owners report directly to the CEO’s & Co-Founders, whilst being heavily supported by our Head of Product Portfolio and our CRO. You will work closely with the Technical Category manager for the edible packaging category, working with them in a “co-founder” type capacity to drive the category’s vision-setting, strategy formulation, and category performance ownership Led by strong values, all Notpla employees are encouraged to take responsibility for their domain, giving a high level of autonomy. Our aim is to build an inspiring culture that's reflected in our working policies ,environment and employees. Besides offering exciting roles and a great working environment, Notpla provides competitive salaries, the potential for EMI Share Options, a zero-carbon pension scheme, discounts with local businesses, and subsidised social activities. Our office first hybrid working policy allows you to work in the manner that maximises your productivity, while still creating a vibrant and collegiate work environment.. We are a social business with regular clubs and events, and we are proud of how our diverse workplace has created a community that is all pushing towards the common goal of making plastic disappear. The role encompasses vision-setting, strategy formulation, and category performance ownership. The role of Edibles Category Owner represents a unique opportunity to lead and shape the category from its foundation, defining business opportunities and driving forward innovation within the edible packaging space. The Edibles Category Owner will act as a steward of cohesive growth and a champion of sustainability and customer experience within this pioneering category. We are looking for a Results driven, collaborative leader who is willing to take on full accountability for the category's success. You will have to be able to combine strategic vision, whilst focusing on measurable goals, using your leadership skills to foster teamwork and align a multifunctional group to achieve its goals. You will need to have prior experience in a Product Manager/Category Owner type role, preferably within the packaging, food or FMCG space. Alongside this you will need to have a demonstrable track record of delivering commercial success, owning the business development process from cradle to grave. You will also need to have strong financial acumen, owning the categories P+L and forecasting models. Alongside all of the above, your day to day responsibilities will include: Oversee the strategy for the entire Edibles product line, balancing short-term execution with long-term growth objectives. Develop and track category KPIs, focusing on measurable outcomes such as product adoption, customer satisfaction, and revenue growth. Identify new business opportunities within the Edibles category, targeting strategic markets and segments. Create and maintain a robust pipeline of leads, transforming prospects into recurring customers. Negotiate and secure long-term agreements with key accounts, ensuring sustained revenue growth and customer retention. Oversee the end-to-end product lifecycle for edible products, from development to launch, ensuring successful execution across all touchpoints, including marketing, pricing, distribution, and customer support. Work closely and collegially with a small but highly skilled team, including a technical project manager and a food scientist, fostering a spirit of collaboration. Collaborate with engineering, chemistry, design, commercial, and finance teams to achieve category goals. Develop and nurture strong relationships with key customers to better understand their needs and create customer-centric solutions. Partner with industry suppliers to ensure a reliable and innovative supply chain for the Edibles category. £45,000 - £60,000 + EMI Share Options

About AQEMIA AQEMIA is a next-gen pharmatech company generating one of the world's fastest-growing drug discovery pipeline. Our mission is to design fast innovative drug candidates for dozens of critical diseases, such as immuno-oncology. Our unique approach leverages quantum-inspired physics algorithms to power generative AI in designing novel drug candidates—without relying on experimental data. We already delivered several drug discovery successes within our internal pipeline and through collaborations with pharmaceutical companies. Our most advanced programs are currently in vivo optimization. About the team you’ll join:As a Senior AI Research Scientist, you will join one of Aqemia’s Drug Discovery Platform AI Teams, composed of 5 AI Researchers, and lead efforts to develop cutting-edge AI algorithms to model protein-ligand systems and predict molecular properties. You will be a hands-on technical expert pushing the boundaries of what AI can do for drug discovery. Your deep knowledge of machine learning, strong coding foundations, and applied experience in model development will play a key role in advancing our Drug Discovery Platform.You will act as a technical mentor, contribute to high-impact R&D projects, and help integrate innovative AI methodologies into real-world drug discovery applications. • Lead the design and the technical implementation of novel ML algorithms with a strong focus on deep learning, generative models, graph neural networks, and physics-informed AI to predict molecular properties and protein-ligand interactions., • Take part in cutting-edge research and bibliographic exploration. You’ll identify relevant recent publications, benchmark promising ideas, and propose model or pipeline improvements., • Act as a mentor to junior team members, offering guidance on system design, model implementation, debugging, and good coding practices., • Collaborate with AI researchers, computational chemists, and drug discovery teams to translate AI models into actionable scientific insights., • Be deeply involved in coding, from prototyping to deploying production-ready models. You should have a strong software engineering mindset and a passion for writing clean, efficient, and scalable code., • Share best practices in deep learning model development, testing, and reproducibility within the team., • Scale AI models for real-world applications, optimizing model efficiency, interpretability, and generalization to unseen chemical spaces., • Strong problem-solving skills, autonomy and a collaborative mindset., • PhD or equivalent practical experience in Machine Learning, Computer Science, Applied Mathematics or a related field, with at least 8 years of experience., • Strong programming skills in Python and proficiency with Deep Learning frameworks (e.g., PyTorch, JAX, TensorFlow)., • Demonstrated hands-on experience implementing and deploying deep learning models in production or research environments., • Strong scientific rigor, curiosity, and ability to perform bibliographic research and exploratory R&D., • Experience in drug discovery, chemistry, or physics., • Experience with physics-informed ML models., • Familiarity with high-performance computing (HPC) and cloud-based ML pipelines.Interview Process- Screening call with Talent Acquisition (30 min)- Interview with your future Manager (45 min)- 1st technical interview: Paper review (1.5 hours)- 2nd technical interview: Take-home ML case (1.5 hours)- Interview with VP Platform and co-founders (1 hour each) Preferred MindsetAt Aqemia, we believe that great science thrives in the right mindset and culture. We are looking for candidates who embody the following principles: Pragmatic and Impact-Driven – Focused on delivering solutions that work in real-world applications, balancing scientific rigor with practical usability.Eagerness to Learn – A strong curiosity for scientific advancements and a willingness to continuously expand your expertise.Love for High Scientific Challenges – Enthusiasm for tackling complex problems at the frontier of AI and drug discovery.Team-Oriented – A collaborative spirit, thriving in an interdisciplinary environment.Humility – Open to feedback and different perspectives, always striving for improvement. Aqemia’s Recruitment team leads all recruitment activities for the company. We will not recognise any notional ownership recruitment companies claim over candidates presented directly to hiring managers without our Recruitment team's consent. Unsolicited resumes sent to us from recruiters do not constitute any type of relationship between the recruiter and Aqemia, and we will not be obligated to pay fees should we hire from those resumes. Why Join Us ? At AQEMIA, we work for a mission: joining us means having your own impact on changing the way drugs are discovered, and helping to shape the direction of our fast-growing company and team. Expanding Drug Discovery Pipeline : Focused on critical therapeutic areas like Oncology, CNS, Immuno-inflammation... with in vivo proof of concept/patent stage programs. Collaborations with top Pharma, including a $140M Sanofi deal.Interdisciplinary Team : brilliant talent from tech and life sciences.DeepTech Recognition: Part of French Tech 120 and France 2030.Prime Location : Based in central Paris and London (King's Cross) with the possibility of 2 remote days per week.International Environment : The work language is English - relocation support and French lessons granted if needed.Strong Financial Backing : $100M raised from leading European and International investors

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You will oversee projects from Hit ID to Candidate delivery, with expertise across DMPK, biology, computational chemistry, and structure-based design, ensuring robust science. Vertex Oxford seeks a Senior Director of Medicinal Chemistry to lead a skilled team in designing and delivering high-quality

Vertex Oxford seeks a Senior Director of Medicinal Chemistry to lead a highly skilled chemistry team in discovering high-quality clinical candidates. You will guide strategies across DMPK, biology, computational chemistry, and process chemistry, mentoring talent and driving projects from Hit ID thro

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Isomorphic Labs in London seeks a Head of Medicinal Chemistry to lead and shape drug discovery at the intersection of chemistry and AI. You will provide scientific leadership for the Medicinal Chemistry team, delivering projects to clinical candidate nomination, and mentor a team of ~25 chemists.

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